Smiling doctorIn 2005, a study published in Current Drug Metabolism identified L-arginine as being able to block asymmetric dimethylarginine (ADMA), an inhibitor of nitric oxide (NO) synthesis1.  When the body releases ADMA, a high level of homocysteine (non-protein amino acid) ​​occurs. Both ADMA and homocysteine are independent risk factors for the development of cardiovascular diseases.

Another study, also published in 2005, examined the use of L-arginine in patients with acute myocardial infarction2.  The study involved 792 participants who either received an oral placebo or L-arginine for 30 days. This was the first study of its kind and the preliminary results show that L-arginine may be very beneficial in reducing cases of acute myocardial infarction.

food and arthritisNutritionists recommend patients with cardiovascular disease, or at risk of developing cardiovascular disease, supplement their diet with L-arginine. Folic acid is also recommended as both compounds help to protect the heart. Folic acid lowers homocysteine, while L-arginine stimulates NO production to support optimal blood circulation and blood pressure. Healthy living and a balanced diet are also important. Treatment should be done in consultation a physician.

1Stühlinger & Stanger: Asymmetric dimethyl-L-arginine (ADMA): a possible link between homocyst (e) ine and endothelial dysfunction. Current Drug Metabolism, 2005, 6, 3-14.
2Bednarz B, et al.: Efficacy and safety of oral l-arginine in acute myocardial infarction. Results of multicenter, randomized, double-blind, placebo-controlled pilot trial ARAMI. Kardiol. Pol. 2005, 62, 421-26